Synthesis, characterization, industrial application and anticancer activity of new N-mustard substituted coumarin derivatives
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International Journal of Engineering Trends and Technology (IJETT) |  |
| © 2017 by IJETT Journal | ||
| Volume-47 Number-6 |
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| Year of Publication : 2017 | ||
| Authors : A Barasara, M Pandya, D Purohit |
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| DOI : 10.14445/22315381/IJETT-V47P255 |
Citation
A Barasara, M Pandya, D Purohit "Synthesis, characterization, industrial application and anticancer activity of new N-mustard substituted coumarin derivatives", International Journal of Engineering Trends and Technology (IJETT), V47(6),344-348 May 2017. ISSN:2231-5381. www.ijettjournal.org. published by seventh sense research group
Abstract
A series of N-mustard Substituted-coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-2g, ASW-2f and ASW-2e) showed GI50 range from 80 to 95 ?g/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity.
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Keywords
4-chloro-3-cyano coumarin, Aniline mustard, Anticancer activity, Nucleophilic substitution, Spectral analysis.