Ribosomes - The Bio Monitors of Protein Synthesis

  IJETT-book-cover  International Journal of Engineering Trends and Technology (IJETT)          
  
© 2019 by IJETT Journal
Volume-67 Issue-1
Year of Publication : 2019
Authors : Eswari beeram
  10.14445/22315381/IJETT-V67I1P209

MLA 

MLA Style: Eswari beeram "Ribosomes - The Bio Monitors of Protein Synthesis" International Journal of Engineering Trends and Technology 67.1 (2019): 49-56.

APA Style: Eswari beeram (2019). Ribosomes - The Bio Monitors of Protein Synthesis. International Journal of Engineering Trends and Technology, 67(1), 49-56.

Abstract
Protein synthesis is the final part of gene expression and is necessary for vital functioning of system. The three parts initiation, elongation and termination are equally important also control of any part leads to entire fidelity of the process. Stalk of ribosome is necessary for translocation of ribosome from A site to P site and also for interaction of tRNA with ribosome. tRNA can acts as structural component of ribosome and head swivelling and use of tRNA hybrids had made the study of translocation of ribosome as possible and finally post translational modifications of proteins proven to be necessary for control of protein synthesis.

Reference
[1] Andreas H. Ratje, Justus Loerke, Aleksandra Mikolajka, Matthias Brunner, Peter W. Hildebrand, Agata L. Starosta, Alexandra Do¨nho¨fer, Sean R. Connell, Paola Fucini, Thorsten Mielke, Paul C. Whitford, Jose´ N. Onuchic, Yanan Yu,Karissa Y. Sanbonmatsu, Roland K. Hartmann, Pawel A. Penczek, Daniel N. Wilson, & Christian M. T. Spahn (2010).Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. NATURE, VOL 468, 713-718.
[2] Arturas Meskauskas and Jonathan D. Dinman (2008). Ribosomal protein L3 functions as a ‘rocker switch’ to aid in coordinating of large subunit-associated functions in eukaryotes and Archaea. Nucleic Acids Research, Vol. 36, No. 19 6175–6186.
[3] Chand S. Mangat and Eric D. Brown (2008). Ribosome biogenesis; the KsgA protein throwsa methyl-mediated switch in ribosome assembly Molecular Microbiology 70(5), 1051–1053.
[4] Eduard V. Bocharov, Alexander G. Sobol, Konstantin V. Pavlov, Dmitry M. Korzhnev, Victor A. Jaravine, Anatoly T. Gudkov, and Alexander S. Arseniev (2004). From Structure and Dynamics of Protein L7/L12 to Molecular Switching in Ribosome. The journal of biological chemistry Vol. 279 (17), pp. 17697–17706.
[5] Gabriella Viero, Lorenzo Lunelli, Andrea Passerini, Paolo Bianchini, Robert J. Gilbert, Paola Bernabò, Toma Tebaldi, Alberto Diaspro, Cecilia Pederzolli, and Alessandro Quattrone (2015). Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes J. Cell Biol. Vol. 208; (5); 581–596.
[6] George E. Fox (2010). Origin and Evolution of the Ribosome Cold Spring Harb Perspect Biol;2:a003483.
[7] Janice M. Zengel, Adam Jerauld, Andrewalker, Markus C. Wahl, and Lasselindahl (2003). The extended loops of ribosomal proteins L4 and L22 arenot required for ribosome assembly or L4-mediated autogenous control. RNA, 9:1188–1197.
[8] Jesper Pallesen, Yaser Hashem, Gürkan Korkmaz, Ravi Kiran Koripella, Chenhui Huang, Måns Ehrenberg, Suparna Sanyal, Joachim Frank (2013). Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1 eLife;2:e00411. DOI: 10.7554/eLife.00411, pp 1-22
[9] Joanna Rorbacha, Fei Gaob, Christopher A. Powella, Aaron R. D’Souzaa, Robert. N. Lightowlers, Michal Minczuka, Zofia. M. A. Chrzanowska-Lightowlers (2016).The human mitochondrial ribosome can switch its structural RNA composition. Proceedings of the National Academy of Sciences, 113(43), 12198-12201.
[10] Maxim Paci and George E. Fox (2015). Major centers of motion in the large ribosomal RNAs. Nucleic Acids Research, Vol. 43 (9), 4640–4649.Srividya Mohan, John Paul Donohue, and Harry F. Noller (2014). Molecular mechanics of 30S subunit head rotation PNAS, vol. 111 (37) 13325–13330.
[11] Shifeng Xue and Maria Barna (2012). Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nature Reviews Molecular Cell Biology Volume 13; 355-69.
[12] Srividya Mohan, John Paul Donohue, and Harry F. Noller (2014). Molecular mechanics of 30S subunit head rotation PNAS, vol. 111 (37) 13325–13330.
[13] V. Ramakrishnan (2002). Ribosome Structure Review and the Mechanism of Translation Cell, Vol. 108, 557–572.

Keywords
Ribosome, LUCA, Head swivelling, Rocker switch, Mitoribosomes