Studying of Complexes of Zn(II) and Co(II) with Acyclovir (2-amino-9-((2-hydroxyethoxy)methyl)-1,9- dihydro-6H-purine-6-OH)

Studying of Complexes of Zn(II) and Co(II) with Acyclovir (2-amino-9-((2-hydroxyethoxy)methyl)-1,9- dihydro-6H-purine-6-OH)

  IJETT-book-cover           
  
© 2024 by IJETT Journal
Volume-72 Issue-1
Year of Publication : 2024
Author : Muratov B.A, Turaev Kh. Kh, Umbarov I.A, Kasimov Sh.A, Nomozov A.K
DOI : 10.14445/22315381/IJETT-V72I1P120

How to Cite?

Muratov B.A, Turaev Kh. Kh, Umbarov I.A, Kasimov Sh.A, Nomozov A.K, "Studying of Complexes of Zn(II) and Co(II) with Acyclovir (2-amino-9-((2-hydroxyethoxy)methyl)-1,9- dihydro-6H-purine-6-OH)," International Journal of Engineering Trends and Technology, vol. 72, no. 1, pp. 202-208, 2024. Crossref, https://doi.org/10.14445/22315381/IJETT-V72I1P120

Abstract
In this paper, the optimal conditions for the synthesis of complex compounds of zinc (II) and cobalt (II) metals [(C8H10N5O3)2Zn] and [(C8H10N5O3)2Co] with aciclovir, one of the drugs used against viruses, were determined. In this case, 0.1 M ZnSO4 and 0.1 M CoSO4 solutions and 0.2 M, 0.4 M and 0.6 molar ethanol solutions of aciclovir were used. During synthesis, the temperature was 50-60 0C, and the mixing duration was two hours. In addition, all reactions were carried out at pH=5. Physico-chemical properties of obtained complex compounds were analyzed by methods such as IR-spectra, DTA and TGA, and Scanning Electron Microscope.

Keywords
Acyclovir, Zinc sulfate, Cobalt sulfate, Ethanol, Scanning Electron Microscope, IR-spectra.

References
[1] Charles E. Carraher Jr et al., “Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity,” Journal of Inorganic and Organometallic Polymers and Materials, vol. 16, pp. 249-257, 2006.
[CrossRef] [Google Scholar] [Publisher Link]
[2] Omudhome Ogbru, Acyclovir, Medicinenet, 2023. [Online]. Available: https://www.medicinenet.com/acyclovir/article.htm
[3] Gertrude B. Elion et al., Selectivity of Action of an Antiherpetic Agent, 9-(2-Hydroxyethoxymethyl) Guanine,” Proceedings of the National Academy of Sciences, vol. 74, no. 12, pp. 5716-5720, 1977.
[CrossRef] [Google Scholar] [Publisher Link]
[4] Eman A. Abd El-Meguid et al., “Novel Benzimidazole Derivatives as Anti-Cervical Cancer Agents of Potential Multitargeting Kinase Inhibitoru Activity,” Arabian Journal of Chemistry, vol. 13, no. 12, pp. 9179-9195, 2020.
[CrossRef] [Google Scholar] [Publisher Link]
[5] J. Arnal et al., “Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Aciclovir,” Journal of Pharmaceutical Sciences, vol. 97, no. 12, pp. 5061-5073, 2008.
[CrossRef] [Google Scholar] [Publisher Link]
[6] Shridhar D. Gunagi, Sharanappa T. Nandibewoor, and Shivamurti A. Chimatadar, “Oxidation of Acyclovir by a Cuprate (III) Periodate Complex in Aqueous Alkaline Media: A Kinetic and Mechanistic Approach,” Journal of Solution Chemistry, vol. 41, pp. 777-792, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[7] Venkata Bharadwaz Vedula et al., “Preparation and Characterization of Nanoparticles of Carboxymethyl Cellulose Acetate Butyrate Containing Acyclovir,” Applied Nanoscience, vol. 6, pp. 197-208, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[8] Sankar Ramakrishnan, and Semant Jain, “Approaches for Enhancing the Bioavailability of Acyclovir: A Critical Review,” International Journal of Pharma and Bio Sciences, vol. 4, no. 4, pp. 623-634, 2013.
[Google Scholar] [Publisher Link]
[9] Manel Chehrouri, and Adil A. Othman, “Synthesis of Novel Seco-Acyclo-N-Diazolyl-Thione Nucleosides Analogous Derived from Acetic Acid: Characterization, Complex Formation with Ions Pb (II), Hg (II) and Antibacterial Activity,” Journal of the Iranian Chemical Society, vol. 19, pp. 893-899, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[10] Aysegul Golcu et al., “Spectroscopic, Analytical and Biological Properties of New Copper (II) Complexes of Antiviral Drug 2- Amino-1, 9-Dihydro-9-[(2-Hydroxyethoxy) Methyl]-6H-Purin-6-One (Acyclovir),” Asian Journal of Chemistry, vol. 21, no. 1, pp. 337-354, 2009.
[Google Scholar] [Publisher Link]
[11] H. Heli et al., “Electrocatalytic Oxidation of the Antiviral Drug Acyclovir on a Copper Nanoparticles-Modified Carbon Paste Electrode,” Journal of Solid State Electrochemistry, vol. 14, pp. 787-795, 2010.
[CrossRef] [Google Scholar] [Publisher Link]
[12] Muratov Botir Abdukodirovich, Khayit Hudainazarovich Turaev, and Umbarov Ibragim Amonovich, “Study of the CU (II) Complex with Acyclovir (2-Amino-9-((2-Hydroxyethoxy) Methyl)-1, 9-Dihydro-6H-Purine-6-OH),” International Bulletin of Engineering and Technology, vol. 2, no. 10, pp. 103-108, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[13] Helmut Sigel, Chemical Properties of Platinum and Other Metal Ion Complexes with Nucleobases and Antiviral Nucleotide Analogues (MICNANA), Schweizerische Eidgenossenschaft Confederation Suisse.
[Publisher Link]
[14] A. Margarita Apostolova et al., “New Competitive Enzyme-Linked Immunosorbent Assay for Determination of Metallothionein in Tissue and Sera,” Talanta, vol. 46, no. 2, pp. 325-333, 1998.
[CrossRef] [Google Scholar] [Publisher Link]
[15] Yevgen Posokhov et al., “Spectral Properties and Complex Formation with Cu2+ Ions of 2- and 4-(N-Arylimino)-Quinolines,” Journal of Photochemistry and Photobiology A: Chemistry, vol. 161, no. 2, pp. 247-254, 2004.
[CrossRef] [Google Scholar] [Publisher Link]
[16] Raquel Delgado et al., “Reaction of Cyclodextrin with N-2, 3-Epoxypropylphthalimide. Preparation, Characterization and Study of a New Substituted Cycloheptaamylose. Effects on the Water Solubility of Drugs,” Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, vol. 28, pp. 205-212, 1997.
[CrossRef] [Google Scholar] [Publisher Link]
[17] Jerzy Boryski, Bozenna Golankiewicz, and Erik De Clercq, “Synthesis and Antiviral Activity of 3-Substituted Derivatives of 3, 9- Dihydro-9-Oxo-5H-Imidazo [1, 2-a] Purines, Tricyclic Analogs of Acyclovir and Ganciclovir,” Journal of Medicinal Chemistry, vol. 34, no. 8, pp. 2380-2383, 1991.
[CrossRef] [Google Scholar] [Publisher Link]