Production of Water-Dispersible Forms of Phytosterols

  IJETT-book-cover  International Journal of Engineering Trends and Technology (IJETT)          
  
© 2020 by IJETT Journal
Volume-68 Issue-10
Year of Publication : 2020
Authors : Ivan Alekseevich Bugaets, Elena Aleksandrovna Butina, Evgeny Olegovich Gerasimenko, Sergey Aleksandrovich Sonin, Albina Anatolievna Kopteva
DOI :  10.14445/22315381/IJETT-V68I10P201

Citation 

MLA Style: Ivan Alekseevich Bugaets, Elena Aleksandrovna Butina, Evgeny Olegovich Gerasimenko, Sergey Aleksandrovich Sonin, Albina Anatolievna Kopteva  "Production of Water-Dispersible Forms of Phytosterols" International Journal of Engineering Trends and Technology 68.10(2020):1-9. 

APA Style:Ivan Alekseevich Bugaets, Elena Aleksandrovna Butina, Evgeny Olegovich Gerasimenko, Sergey Aleksandrovich Sonin, Albina Anatolievna Kopteva. Production of Water-Dispersible Forms of Phytosterols  International Journal of Engineering Trends and Technology, 68(10),1-9.

Abstract
The research is devoted to the development of a method for producing phytosterols in a water-dispersible form by encapsulating a finely dispersed suspension of phytosterols with a nonionic surfactant. As a surfactant, it is proposed to use powdered sunflower lecithin. The results of studies of producing emulsions and a powdered encapsulated form of phytosterols are presented

Reference

[1] L. G. Ipatova, "Zhirovye produkty dlja zdorovogo pitanija. Sovremennyj vzgljad [Fat foods for a healthy diet. Modern view]". Moscow: DeLi Print, 2009.
[2] N. A. Tjukavkina, S. J. Zuraban, V. L. Beloborodov, and E. Al., "Organicheskaja himija: uchebnik dlja vuzov: v 2 kn. Kn. 2: Special’nyj kurs [Organic chemistry: textbook for universities: in 2 books]". Moscow: Drofa, 2008.
[3] S. M. Mel’nikov, J. W. . Seijen ten Hoorn, and B. Bertrand, “Can cholesterol absorption be reduced by phytosterols and phytostanols via a cocrystallization mechanism?,” Chem. Phys. Lipids, vol. 127, no. 1, pp. 15–33, Jan. 2004, doi: 10.1016/j.chemphyslip.2003.08.007.
[4] A. Berger, P. J. H. Jones, and S. S. Abumweis, “Plant sterols: Factors affecting their efficacy and safety as functional food ingredients,” Lipids Heal. Dis, vol. 3, pp. 5–23, 2004, doi: 10.1186/1476-511X-3-5.
[5] P. Fernandes and J. M. S. Cabral, “Phytosterols: Applications and recovery methods,” Bioresour. Technol., vol. 98, no. 12, pp. 2335–2350, Sep. 2007, doi: 10.1016/j.biortech.2006.10.006.
[6] J. QuÍlez, “Potential uses and benefits of phytosterols in diet: present situation and future directions,” Clin. Nutr., vol. 22, no. 4, pp. 343–351, Aug. 2003, doi: 10.1016/S0261- 5614(03)00060-8.
[7] J. Plat and R. P. Mensink, “Plant Stanol and Sterol Esters in the Control of Blood Cholesterol Levels: Mechanism and Safety Aspects,” Am. J. Cardiol., vol. 96, no. 1, pp. 15–22, Jul. 2005, doi: 10.1016/j.amjcard.2005.03.015.
[8] E. A. Trautwein, G. S. M. J. E. Duchateau, Y. Lin, S. M. Mel’nikov, H. O. F. Molhuizen, and F. Y. Ntanios, “Proposed mechanisms of cholesterol-lowering action of plant sterols,” Eur. J. Lipid Sci. Technol., vol. 105, no. 34, pp. 171–185, Apr. 2003, doi: 10.1002/ejlt.200390033.
[9] S. Rozner and N. Garti, “The activity and absorption relationship of cholesterol and phytosterols,” Colloids Surfaces A Physicochem. Eng. Asp., vol. 282–283, pp. 435–456, Jul. 2006, doi: 10.1016/j.colsurfa.2005.12.032.
[10] D. Kritchevsky and S. C. Chen, “Phytosterols—health benefits and potential concerns: a review,” Nutr. Res., vol. 25, no. 5, pp. 413–428, May 2005, doi: 10.1016/j.nutres.2005.02.003.
[11] E. Heggen et al., “Plant sterols from rapeseed and tall oils: Effects on lipids, fat-soluble vitamins and plant sterol concentrations,” Nutr. Metab. Cardiovasc. Dis., vol. 20, no. 4, pp. 258–265, May 2010, doi: 10.1016/j.numecd.2009.04.001.
[12] EFSA, “Plant Stanols and Plant Sterols and Blood LDLCholesterol - Scientific Opinion of the Panel on Dietetic Products Nutrition and Allergies on a request from the European Commission and a similar request from France in relation to the authorization procedure,” EFSA J., vol. 7, no. 7, p. 1175, Jul. 2009, doi: 10.2903/j.efsa.2009.1175.
[13] EFSA, “Scientific Opinion on the substantiation of health claims related to plant sterols and plant stanols and maintenance of normal blood cholesterol concentrations (ID 549, 550, 567, 713, 1234, 1235, 1466, 1634, 1984, 2909, 3140), and maintenance of normal pr,” EFSA J., vol. 8, no. 10, p. 1813, Oct. 2010, doi: 10.2903/j.efsa.2010.1813.
[14] “Metodicheskie rekomendacii MR 2.3.1.2432-08 «Normy fiziologicheskih potrebnostej v jenergii i pishhevyh veshhestvah dlja razlichnyh grupp naselenija Rossijskoj Federacii» (Methodical recommendations MR 2.3.1.2432-08 "Norms of physiological requirements in.” .
[15] A. A. Kruglyakova and G. V. Ramenskaya, “Beta-sitosterol: properties, approaches to quantitative determination,” Bull. Natl. Med. Surg. Cent. N.I. Piragova, vol. 11, no. 4, pp. 35–38, 2016.
[16] R. Cantrill, “Phytosterols, phytostanols and their esters,” CTA, pp. 1–13, 2008, [Online]. Available: www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/69/Phytost erols.pdf .
[17] P. Laakso, “Analysis of sterols from various food matrices,” Eur. J. Lipid Sci. Technol., vol. 107, no. 6, pp. 402–410, Jun. 2005, doi: 10.1002/ejlt.200501134.
[18] L. G. Ipatova, “Development of the first domestic spreads enriched with phytosterols,” Dairy Ind., vol. 11, 2011.
[19] S. Saeidnia, “The Story of Beta-sitosterol- A Review,” European J. Med. Plants, vol. 4, no. 5, pp. 590–609, Jan. 2014, doi: 10.9734/EJMP/2014/7764.
[20] X. Y. Zhang, Y. Peng, and G. Q. He, “Improved Water- Solubility of Phytosterol by Hydroxypropyl-?-Cyclodextrin,” Adv. Mater. Res., vol. 554–556, pp. 922–925, Jul. 2012, doi: 10.4028/www.scientific.net/AMR.554-556.922.
[21] D. Von Chon, “Water-soluble sterol derivatives for lowering a cholesterol level, and method for preparing same,” WO2010126276A2, 2010.
[22] W.-F. Leong, O.-M. Lai, K. Long, Y. B. Che Man, M. Misran, and C.-P. Tan, “Preparation and characterisation of watersoluble phytosterol nanodispersions,” Food Chem., vol. 129, no. 1, pp. 77–83, Nov. 2011, doi: 10.1016/j.foodchem.2011.04.027.
[23] A. Ubeyitogullari and O. N. Ciftci, “Phytosterol nanoparticles with reduced crystallinity generated using nanoporous starch aerogels,” RSC Adv., vol. 6, no. 110, pp. 108319–108327, 2016, doi: 10.1039/C6RA20675A.
[24] X. Zhang, J. Yu, and A. Zeng, “Optimization and modeling for the synthesis of sterol esters from deodorizer distillate by lipase-catalyzed esterification,” Biotechnol. Appl. Biochem., vol. 64, no. 2, pp. 270–278, Mar. 2017, doi: 10.1002/bab.1476.
[25] R. Engel and H. Schubert, “Formulation of phytosterols in emulsions for increased dose response in functional foods,” Innov. Food Sci. Emerg. Technol., vol. 6, no. 2, pp. 233–237, Jun. 2005, doi: 10.1016/j.ifset.2005.01.004.
[26] L. I. Christiansen, J. T. Rantanen, A. K. von Bonsdorff, M. A. Karjalainen, and J. K. Yliruusi, “A novel method of producing a microcrystalline ?-sitosterol suspension in oil,” Eur. J. Pharm. Sci., vol. 15, no. 3, pp. 261–269, Apr. 2002, doi: 10.1016/S0928-0987(01)00223-8.
[27] A. Akbarzadeh et al., “Liposome: classification, preparation, and applications,” Nanoscale Res. Lett., vol. 8, no. 1, p. 102, Dec. 2013, doi: 10.1186/1556-276X-8-102.
[28] V. I. Shvets, “Fosfolipidy v biotekhnologiyakh [Phospholipids in biotechnology],” Vestn. MIKhT, vol. 4, no. 4, pp. 4–25, 2009.
[29] O. M. Ipatova, “Primeneniye rastitel’nykh fosfolipidov kak biologicheski aktivnykh ingrediyentov: nastoyashcheye i budushcheye [The use of plant phospholipids as biologically active ingredients: the present and the future],” Probl. Econ. Manag. trade Ind., vol. 4, pp. 23–33, 2014.
[30] H. Jens, “Lecithin The Natural and Powerful Substance,” in 15- th International Conference «Phospholipids: New Opportunities in Technology, Analytical, Chemistry and Applicatinons», 2016.
[31] B. Burruano, R. D. Bruce, M. R. Hoy, And J. D. Higgins, “Method for producing water dispersible sterol formulations,” US-6054144-A, 2020.
[32] X. Meng, Q. Pan, and Y. Liu, “Preparation and properties of phytosterols with hydroxypropyl ?-cyclodextrin inclusion complexes,” Eur. Food Res. Technol., vol. 235, no. 6, pp. 1039– 1047, Dec. 2012, doi: 10.1007/s00217-012-1833-5.
[33] E. Lerchenfeld and D. Strijel, “A method for producing a phytosterol disperse system for beverages (variants),” RU2338430, 2008.
[34] S. Damodaran, K. L. Parkin, and O. R. Fennema, "Chemistry of food products". St. Petersburg: ID “Profession,” 2012.

Keywords
phytosterols, lecithin, emulsions, encapsulation.