IJBTT

PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery

PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery
	© 2022 by IJETT Journal
	Volume-70 Issue-5
	Year of Publication : 2022
	Authors : Chandbadshah S B V J, Giriraj Mannayee
	DOI :  10.14445/22315381/IJETT-V70I5P203

How to Cite?

Chandbadshah S B V J, Giriraj Mannayee, "PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery," International Journal of Engineering Trends and Technology, vol. 70, no. 5, pp. 15-23, 2022. Crossref, https://doi.org/10.14445/22315381/IJETT-V70I5P203

Abstract
Cone-shaped 6x6 microneedle arrays with a height of 600 µm and diameter of 300 µm for transdermal vaccine delivery were fabricated with Polyethylene glycol diacrylate (PEGDA) material by projection micro stereo-lithography (P?SL) method. Nano indenter was utilized to estimate the young’s modulus and hardness of PEGDA materials. Nanoindentation was used to randomly perform compression tests on several different needles to calculate the largest forces that the PEGDA microneedles can sustain. It was identified that developed forces are quite more than the opposing forces offered by skin structure. The biocompatible features of PEGDA have made the microneedles suitable for advanced transdermal vaccine delivery applications, and they can be used as a solid or coated microneedles array for vaccine delivery

Keywords
Array, cone, Fabrication, Microneedle, PEGDA, Vaccine.

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