PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery

  IJETT-book-cover  International Journal of Engineering Trends and Technology (IJETT)          
  
© 2022 by IJETT Journal
Volume-70 Issue-5
Year of Publication : 2022
Authors : Chandbadshah S B V J, Giriraj Mannayee
DOI :  10.14445/22315381/IJETT-V70I5P203

Citation 

MLA Style: Chandbadshah S B V J., and Giriraj Mannayee. "PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery." International Journal of Engineering Trends and Technology, vol. 70, no. 5, May. 2022, pp. 15-23. Crossref, https://doi.org/10.14445/22315381/IJETT-V70I5P203

APA Style:Chandbadshah S B V J., & Giriraj Mannayee. (2022). PEGDA Microneedle Arrays Fabrication and Investigation of Mechanical Properties for Transdermal Vaccine Delivery. International Journal of Engineering Trends and Technology, 70(5), 15-23. https://doi.org/10.14445/22315381/IJETT-V70I5P203

Abstract
Cone-shaped 6x6 microneedle arrays with a height of 600 µm and diameter of 300 µm for transdermal vaccine delivery were fabricated with Polyethylene glycol diacrylate (PEGDA) material by projection micro stereo-lithography (P?SL) method. Nano indenter was utilized to estimate the young’s modulus and hardness of PEGDA materials. Nanoindentation was used to randomly perform compression tests on several different needles to calculate the largest forces that the PEGDA microneedles can sustain. It was identified that developed forces are quite more than the opposing forces offered by skin structure. The biocompatible features of PEGDA have made the microneedles suitable for advanced transdermal vaccine delivery applications, and they can be used as a solid or coated microneedles array for vaccine delivery

Keywords
Array, cone, Fabrication, Microneedle, PEGDA, Vaccine.

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