An Unsupervised Deep Feature Selection and Ensemble Deep Learning Model for Cancer Classification

  IJETT-book-cover  International Journal of Engineering Trends and Technology (IJETT)          
  
© 2022 by IJETT Journal
Volume-70 Issue-9
Year of Publication : 2022
Authors : K. Prema, A. Kumar Kombaiya
DOI : 10.14445/22315381/IJETT-V70I9P203

How to Cite?

K. Prema, A. Kumar Kombaiya, "An Unsupervised Deep Feature Selection and Ensemble Deep Learning Model for Cancer Classification," International Journal of Engineering Trends and Technology, vol. 70, no. 9, pp. 20-33, 2022. Crossref, https://doi.org/10.14445/22315381/IJETT-V70I9P203

Abstract
Microarray technology is a principle to begin and verify the antibody microarrays in a registered series of patents. Within a particular trial, a Microarray Data Analysis (MDA) is utilized to identify the patterns of thousands of genes. The MD consists of a large volume of gene expression data for detecting cancer diseases. But, the imbalanced class label instances in microarray gene datasets and initialized parameter value for the classifier lead to over-fitting and under-fitting problems in cancer classification. Therefore, in this article, a stacking ensemble of Deep cluster-based Deep Learning (DL) systems for Cancer Classification is designed to overcome the abovementioned difficulty by using many learning models to build one ideal predictive model. The developed model is classified into three sections. First, a Modified Harmony Search Algorithm and Modified Kernel-based Fuzzy C-Means (MHSAMKFC) are developed to eliminate huge redundant features effectively. Second, the MHSAMKFC with Convolutional Neural Network (CNN) classifier is proposed to handle uncertainties in the labelled training dataset to improve the classifier performance. Third, the over-fitting and the under-fitting problem of MHSAMKFC-CNN is reduced by the ensemble method, which uses multiple learning models to provide better prediction accuracy. The whole process is termed to be En-MHSAMKFC-CNN. Finally, experimentation is carried out on four Gene Expression Microarray (GEM) datasets and verified that the En-MHSAMKFC-CNN improves the classification performance of SVM, KNN, RF and ANN classifiers.

Keywords
Microarray Data Analysis, Convolutional Neural Network, Fuzzy C-Means, Harmony Search Algorithm, Cancer Classification.

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